Valentina Zuco Selected Research

namitecan

2/2014	Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number.
7/2012	The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.
2/2010	Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma.
7/2008	Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
6/2008	Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

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Valentina Zuco Research Topics

Disease

29	Neoplasms (Cancer) 05/2024 - 08/2002
15	Carcinoma (Carcinomatosis) 04/2016 - 08/2002
6	Sarcoma (Soft Tissue Sarcoma) 05/2024 - 07/2012
6	Prostatic Neoplasms (Prostate Cancer) 06/2020 - 08/2002
4	Mesothelioma 10/2022 - 08/2016
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2015 - 06/2008
3	Rhabdoid Tumor (Rhabdoid Tumors) 05/2024 - 12/2023
2	Ovarian Neoplasms (Ovarian Cancer) 11/2021 - 03/2011
2	Leukemia 07/2007 - 07/2005
2	Melanoma (Melanoma, Malignant) 03/2003 - 01/2002
1	Desmoplastic Small Round Cell Tumor 01/2023
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Triple Negative Breast Neoplasms 05/2021
1	Liposarcoma 03/2021
1	Hypertension (High Blood Pressure) 01/2018
1	medullary Thyroid cancer 08/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2015
1	Lung Neoplasms (Lung Cancer) 03/2015
1	Neoplasm Metastasis (Metastasis) 03/2015
1	Multiple Myeloma 01/2013
1	Rhabdomyosarcoma 07/2012
1	Hypersensitivity (Allergy) 06/2008
1	Breast Neoplasms (Breast Cancer) 03/2004
1	Brain Neoplasms (Brain Tumor) 01/2002
1	Neuroectodermal Tumors (Neuroectodermal Tumor) 01/2002

Drug/Important Bio-Agent (IBA)

6	CamptothecinIBA 07/2012 - 04/2003
5	Antineoplastic Agents (Antineoplastics)IBA 01/2023 - 11/2010
5	Cisplatin (Platino)FDA LinkGeneric 11/2021 - 07/2005
5	namitecanIBA 02/2014 - 06/2008
4	Irinotecan (Camptosar)FDA LinkGeneric 01/2023 - 07/2008
4	Proteins (Proteins, Gene)FDA Link 06/2020 - 03/2004
4	3- (4'- hydroxy- 3'- adamantylbiphenyl- 4- yl)acrylic acidIBA 03/2011 - 03/2003
4	RetinoidsIBA 03/2011 - 03/2003
3	tazemetostatIBA 05/2024 - 12/2023
3	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2022
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2023 - 07/2019
3	MicroRNAs (MicroRNA)IBA 10/2022 - 01/2017
3	TubulinIBA 08/2016 - 05/2009
3	Histone Deacetylase InhibitorsIBA 03/2015 - 03/2010
3	Topotecan (Hycamtin)FDA LinkGeneric 02/2010 - 04/2003
3	Hormones (Hormone)IBA 09/2004 - 08/2002
2	Phosphotransferases (Kinase)IBA 05/2024 - 01/2013
2	Vinorelbine (Navelbine)FDA LinkGeneric 01/2023 - 04/2017
2	selinexorIBA 05/2021 - 03/2021
2	SurvivinIBA 05/2021 - 03/2021
2	Antimitotic AgentsIBA 04/2017 - 06/2008
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 07/2012 - 04/2003
2	Histone Deacetylases (Histone Deacetylase)IBA 04/2012 - 03/2010
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2011 - 09/2004
2	9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA 02/2010 - 03/2004
2	ST 1481 (Gimatecan)IBA 03/2004 - 04/2003
2	Cytostatic AgentsIBA 04/2003 - 01/2002
1	TransposasesIBA 05/2024
1	pazopanib FDA Link 01/2023
1	eribulin FDA Link 01/2023
1	TrabectedinIBA 01/2023
1	Angiopoietin-2IBA 01/2022
1	trifluridine tipiracil drug combinationIBA 01/2022
1	regorafenibIBA 01/2022
1	TocotrienolsIBA 11/2021
1	Ifosfamide FDA LinkGeneric 07/2019
1	Gemcitabine FDA Link 07/2019
1	Nucleic AcidsIBA 01/2019
1	AnticoagulantsIBA 01/2018
1	Adenosine Triphosphate (ATP)IBA 12/2017
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 12/2017
1	LipidsIBA 01/2017
1	IsoindolesIBA 08/2016
1	naphthalenediimideIBA 08/2016
1	Histones (Histone)IBA 04/2016
1	BI 2536IBA 04/2015
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 04/2015
1	Messenger RNA (mRNA)IBA 03/2015
1	ErbB Receptors (EGF Receptor)IBA 02/2014
1	Cetuximab (Erbitux)FDA Link 02/2014
1	Proteasome InhibitorsIBA 01/2013
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2013
1	ChemokinesIBA 07/2012
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2012
1	3- (3'- adamantan- 1- yl- 4'- methoxybiphenyl- 4- yl)- 2- propenoic acidIBA 03/2011
1	Taxoids (Taxanes)IBA 03/2011
1	Cytotoxins (Cytolysins)IBA 11/2010
1	Platinum Compounds (Compounds, Platinum)IBA 08/2010
1	Vorinostat FDA Link 03/2010
1	CurcuminIBA 03/2010
1	PanobinostatIBA 03/2010
1	pifithrinIBA 06/2008
1	DNA (Deoxyribonucleic Acid)IBA 07/2005
1	Mitoxantrone (Novantrone)FDA LinkGeneric 03/2004
1	AcidsIBA 03/2003
1	IDN 5109 (BAY 59-8862)IBA 08/2002
1	taxaneIBA 08/2002
1	AndrogensIBA 08/2002
1	Betulinic AcidIBA 01/2002
1	TriterpenesIBA 01/2002

Therapy/Procedure

11	Therapeutics 05/2024 - 08/2002
4	Radiotherapy 01/2020 - 01/2017
1	Drug Therapy (Chemotherapy) 03/2015
1	Oral Administration 03/2003